Detective Rebecca Madsen and Alcatraz historian Doctor Diego Soto team up with a secret agency that is dedicated to finding and catching inmates from the infamous prison who went missing 50 years ago and are reappearing today. The special task force includes Emerson Hauser and Doctor Lucy Banerjee.
On March 21, 1963, the inmates and guards at Alcatraz prison mysteriously disappear. To cover up the problem, the government reports to the public that the prison has been closed because of unsafe conditions. A secret government unit was set-up to find the prisoners. Now, in the present-day, the inmates begin returning – unaged and unaware of where they have spent the missing decades – and continue their criminal ways. They are acting out of character and appear to be searching for specific objects. A federal agent employs a police officer and a conspiracy theory novelist to help track them down.